Thermo Fisher Scientific CD21 Recombinant Rabbit Monoclonal Antibody (001)
인간 CD21 단백질을 인식하는 재조합 토끼 단일클론 항체로, 높은 특이성과 감도를 제공합니다. ELISA에 적합하며, 로트 간 일관성과 동물 유래 성분이 없는 포뮬레이션을 특징으로 합니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- ELISA (ELISA)
Tested Dilution: 1:5,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 001 |
| Immunogen | Recombinant Human CD21 Protein (Met1–Arg971) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2786118 |
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
This antibody has specificity for Human CD21.
Target Information
CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially breakdown fragments attached to complement-activating surfaces or antigens.
It plays a key role in:
- Uptake and retention of immunocomplexes
- Survival of memory B cells
- Development and maintenance of humoral response to T-dependent antigens
CD21 also acts as a receptor for Epstein-Barr virus and is involved in prion targeting to follicular dendritic cells, aiding neuroinvasion after peripheral exposure.
A soluble form (sCD21) retains ligand-binding ability.
CD21 interacts with CD23 and forms complexes with CD19, CD81, and Leu13 for B cell activation.
Genetic variations in CD21 are linked to susceptibility to systemic lupus erythematosus type 9 (SLEB9).
Alternative splicing produces different isoforms of CD21.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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