Thermo Fisher Scientific Glutathione S-Transferase Mu2 (GSTM2) Monoclonal Antibody (CPTC-GSTMu2-2)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

Eight distinct classes of soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
GSTM2 belongs to the mu class, which functions in detoxification of electrophilic compounds—including carcinogens, therapeutic drugs, environmental toxins, and oxidative stress products—by conjugation with glutathione.

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. The mu class enzymes are encoded in a gene cluster on chromosome 1p13.3 and are highly polymorphic, influencing individual susceptibility to toxins and drug responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.