Thermo Fisher Scientific MATN3 Polyclonal Antibody
MATN3 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot과 면역세포염색(ICC/IF)에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 13 amino acid peptide from near the center of human MATN3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155167 |
Product Specific Information
- Suggested positive control: rat thymus tissue lysate
- PA5-20727 can be used with blocking peptide PEP-0841.
Target Information
Matrilins (MATNs) are a family of non-collagenous extracellular matrix (ECM) proteins consisting of four known members that play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs).
MATN1 and MATN3 are specifically expressed in cartilage and are among the most up-regulated ECM proteins during chondrogenesis.
MATN3 is composed of a single N-terminal von Willebrand Factor A (vWFA) domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain, whereas MATN1 contains two vWFA domains separated by one EGF-like domain.
Both MATN1 and MATN3 may play roles in modulating chondrogenesis during chondrocyte differentiation.
Mutations in MATN3 are associated with various inherited chondrodysplasias. Aberrant expression and processing of MATN3 are hallmarks of conventional cartilaginous neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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