Thermo Fisher Scientific MATN3 Polyclonal Antibody
Thermo Fisher Scientific의 MATN3 Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 Matrilin 3 단백질 검출에 적합합니다. Western blot 및 면역세포화학(ICC/IF)에 사용 가능하며, 항원 친화 크로마토그래피로 정제된 고순도 항체입니다. 연구용으로만 사용됩니다.
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- PA520726
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 13 amino acid peptide from near the carboxy terminus of human MATN3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152182 |
Product Specific Information
- Suggested positive control: NIH-3T3 cell lysate
- Compatible blocking peptide: PEP-0840
Target Information
Matrilins (MATNs) are a family of non-collagenous extracellular matrix (ECM) proteins consisting of four known members that play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs).
MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis.
MATN3 is composed of a single N-terminal von Willebrand Factor A (vWFA) domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain, whereas MATN1 contains two vWFA domains separated by one EGF-like domain.
Both MATN1 and MATN3 may modulate chondrogenesis during chondrocyte differentiation.
Mutations in the MATN3 gene have been associated with various inherited chondrodysplasias.
Aberrant expression and processing of MATN3 are known hallmarks of conventional cartilaginous neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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