Thermo Fisher Scientific SIGLEC5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Concentration: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
EKPVYELQVQ KSVTVQEGLC VLVPCSFSYP WRSWYSSPPL YVYWFRDGEI PYYAEVVATN NPDRRVKPET QGRFRLLGDV QKKNCSLSIG DARMEDTGSY FFRVERGRDV KYSYQQNKLN LEVTALIEKP DIHFLEPLES GRPTRLSCSL PGSCEAGPPL TFSWTGNALS PLDPETTRSS ELTLTPRPED HGTNLTCQMK RQGAQVTTER TVQLNVSYAP QTITIFRNGI ALEILQNTSY LPVLEGQALR LLCDAPSNPP AHLSWFQGSP ALNATPISNT GILELRRVRS AEEGGFTCRA QHPLGFLQIF LNLSVYSLPQ LLGPSCSWEA EGLHCRCSFR ARPAPSLCWR LEEKPLEGNS SQGSFKVNSS SAGPWANSSL ILHGGLSSDL KVSCKAWNIY GSQSGSVLLL QGRSNLGT

Target Information

SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells.
It binds equally to α2,3-linked and α2,6-linked sialic acid.
The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
This molecule is expressed by monocytic/myeloid lineage cells, found at high levels in peripheral blood leukocytes, spleen, and bone marrow, and at lower levels in lymph node, lung, appendix, placenta, pancreas, and thymus.
It is expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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