Thermo Fisher Scientific SIGLEC5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 17-434 of human SIGLEC5 (NP_0038211) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SIGLEC F (SIGLEC5),uniProtId:O15389-1,ncbiNodeId:9606,antigenRange:17-434,antigenLength:551,antigenImageFileName:PA5-110370_SIGLEC_F_SIGLEC5_O15389-1_Rabbit.svg,antigenImageFileNamePDP:PA5-110370_SIGLEC_F_SIGLEC5_O15389-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

4.51 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2855781

Product Specific Information

Immunogen sequence: EKPVYELQVQ KSVTVQEGLC VLVPCSFSYP WRSWYSSPPL YVYWFRDGEI PYYAEVVATN NPDRRVKPET QGRFRLLGDV QKKNCSLSIG DARMEDTGSY FFRVERGRDV KYSYQQNKLN LEVTALIEKP DIHFLEPLES GRPTRLSCSL PGSCEAGPPL TFSWTGNALS PLDPETTRSS ELTLTPRPED HGTNLTCQMK RQGAQVTTER TVQLNVSYAP QTITIFRNGI ALEILQNTSY LPVLEGQALR LLCDAPSNPP AHLSWFQGSP ALNATPISNT GILELRRVRS AEEGGFTCRA QHPLGFLQIF LNLSVYSLPQ LLGPSCSWEA EGLHCRCSFR ARPAPSLCWR LEEKPLEGNS SQGSFKVNSS SAGPWANSSL ILHGGLSSDL KVSCKAWNIY GSQSGSVLLL QGRSNLGT

Target Information

SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. This protein binds equally to alpha2,3-linked and alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. This molecule is expressed by monocytic/myeloid lineage cells. SIGLEC5 is found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. It is expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.