Thermo Fisher Scientific SIGLEC12 Polyclonal Antibody
Thermo Fisher Scientific의 SIGLEC12 폴리클로날 항체는 인간 SIGLEC12 단백질(aa 20-210)을 기반으로 제작된 Rabbit IgG 항체입니다. Western blot 및 ELISA에 사용 가능하며, 고순도 친화 크로마토그래피 정제 제품으로 안정적 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific SIGLEC12 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20–210 of human SIGLEC12 (NP_443729.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.98 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855780 |
Product Specific Information
Immunogen sequence:
EQKDYLLTMQ KSVTVQEGLC VSVLCSFSYP QNGWTASDPV HGYWFRAGDH VSRNIPVATN NPARAVQEET RDRFHLLGDP QNKDCTLSIR DTRESDAGTY VFCVERGNMK WNYKYDQLSV NVTASQDLLS RYRLEVPESV TVQEGLCVSV PCSVLYPHYN WTASSPVYGS WFKEGADIPW DIPVATNTPS G
Target Information
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to sialic acid moieties on glycolipids and glycoproteins.
This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs, characterized by:
- An extracellular V-set immunoglobulin-like domain followed by two C2-set domains
- Cytoplasmic tyrosine-based motifs (ITIM and SLAM-like)
Upon tyrosine phosphorylation, the encoded protein recruits SHP1 and SHP2 phosphatases, suggesting a role in negative regulation of macrophage signaling as an inhibitory receptor.
Located on 19q13.4, this gene clusters with other SIGLEC3-like genes.
Alternatively spliced transcript variants encoding distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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