Thermo Fisher Scientific CLCN1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CLCN1 protein. Validated for Western blot with high purity (>95%) and strong specificity. Suitable for detecting endogenous CLCN1 at 110 kDa. Provided as liquid form with 1 mg/mL concentration for reliable res...
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Thermo Fisher Scientific CLCN1 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in human CLCN1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553930 |
Product Specific Information
This antibody detects endogenous CLCN1 protein at a molecular weight of approximately 110 kDa.
Purity is greater than 95% by SDS-PAGE.
Target Information
Voltage-dependent chloride channels (CLCs) regulate chloride ion trafficking, essential for cellular function.
CLCs influence muscle and nerve excitability, solute transport, and cell volume maintenance.
- CLC1: Highly expressed in skeletal muscle; mutations cause myotonia and renal salt wasting.
- CLC2: Expressed in epithelial tissues (e.g., lung); potential target for cystic fibrosis therapy.
- CLC3: Abundant in neuronal tissue.
- CLC4: Found in skeletal and cardiac muscle and brain.
- CLC5: Mutations cause Dent’s disease (proteinuria, hypercalciuria).
- CLC6, CLC7: Broad expression in testis, kidney, brain, and muscle.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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