Thermo Fisher Scientific ZO-2 Monoclonal Antibody (3E8D9)
ZO-2 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단일클론 항체로, WB, IHC, ICC, ELISA, IP 등 다양한 분석에 사용 가능. 0.5 mg/mL 농도의 액상 형태이며, Protein A로 정제됨. PBS(pH 7.4) 버퍼에 0.1% sodium azide 포함, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 7 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1 µg/mL | View 6 publications |
| Flow Cytometry (Flow) | - | View 1 publication |
| ELISA | Assay-dependent | View publications |
| Immunoprecipitation (IP) | Assay-dependent | View 3 publications |
| ChIP assay (ChIP) | - | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human |
| Published Species | Dog, Fish, Human, Mouse |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E8D9 |
| Immunogen | Synthetic peptide derived from internal amino acids of human ZO-2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533321 |
Target Information
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed in all nucleated hematopoietic cells, comprising about 10% of lymphocyte surface proteins. It is absent on non-hematopoietic cells and tissues. CD45 glycoprotein plays a crucial role in lymphocyte development and antigen signaling, regulating Src-family kinases. Multiple isoforms exist due to alternative splicing, differing in extracellular domains but sharing transmembrane and cytoplasmic domains. CD45RA, an isoform, shows restricted expression among lymphoid subtypes. CD45 regulates T- and B-cell receptor signaling, suppresses JAK kinases, and influences cytokine receptor signaling, integrin-mediated pathways, apoptosis, and other immune functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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