Thermo Fisher Scientific KIRREL3 Polyclonal Antibody
Thermo Fisher의 KIRREL3 다클론 항체로, Mouse KIRREL3/NEPH2 단백질을 인식합니다. IHC(P) 및 ELISA에 적합하며, 비결합형 액상 형태로 제공됩니다. 방부제 무첨가 제품으로 냉장 또는 냉동 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,500–1:10,000 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Mouse KIRREL3/NEPH2 protein (Met1–Ala535) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Maintain refrigerated at 2–8 °C for up to 1 month. For long-term storage, store at −20 °C. |
| Shipping Conditions | Wet ice |
| RRID | AB_2788638 |
Product Specific Information
- Preservative-free formulation.
- It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.
- Specificity: Mouse KIRREL3/NEPH2.
Target Information
The protein encoded by the KIRREL3 gene belongs to the nephrin-like protein family. These proteins are expressed in the fetal and adult brain, as well as in podocytes of kidney glomeruli. The cytoplasmic domains interact with the C-terminus of podocin, contributing to size- and charge-selective ultrafiltration.
KIRREL3 functions as a synaptic cell adhesion molecule containing multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. Mutations in this gene are associated with several neurological and cognitive disorders. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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