Thermo Fisher Scientific CD137L/4-1BBL/TNFSF9 Monoclonal Antibody (CD137L, 1547)
인간 CD137L을 인식하는 Mouse IgG2a 단클론 항체로, IHC, ICC/IF, Flow Cytometry에 사용 가능. 200 µg/mL 농도의 액상 제품이며 Protein A/G 정제. 항원은 재조합 인간 CD137L 전장 단백질. 연구용으로만 사용.
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Thermo Fisher Scientific CD137L/4-1BBL/TNFSF9 Monoclonal Antibody (CD137L, 1547)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2–4 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CD137L, 1547 |
| Immunogen | Recombinant full-length human CD137L protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
CD137 ligand (CD137L) is a type II membrane protein and a member of the TNF superfamily. It acts as a co-stimulatory molecule expressed on antigen-presenting cells such as dendritic cells, monocytes/macrophages, and B cells, and is upregulated upon activation.
Its receptor, CD137/4-1BB, is found on various cells including inflamed endothelial cells, where interaction with CD137L promotes monocyte extravasation.
Activated T cells express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity.
CD137L is expressed on most B-cell lymphomas (mantle cell, follicular, diffuse large B-cell), but absent in Hodgkin and T-cell lymphomas. It is also found in carcinoma cell lines, suggesting involvement in T cell–tumor cell interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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