Thermo Fisher Scientific TRAF2 Recombinant Rabbit Monoclonal Antibody (3S2A8)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:25,000-1:100,000

-

ELISA (ELISA)

1 µg/mL

-

Immunoprecipitation (IP)

0.5 µg-4 µg antibody for 200 µg-400 µg extracts of

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

3S2A8

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 190-350 of human TRAF2 (NP_066961.2). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TRAF2,uniProtId:Q12933-1,ncbiNodeId:9606,antigenRange:190-350,antigenLength:501,antigenImageFileName:MA5-51192_TRAF2_Q12933-1_Rabbit.svg,antigenImageFileNamePDP:MA5-51192_TRAF2_Q12933-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_3093784

Product Specific Information

Immunogen sequence: DGCGKKKIPR EKFQDHVKTC GKCRVPCRFH AIGCLETVEG EKQQEHEVQW LREHLAMLLS SVLEAKPLLG DQSHAGSELL QRCESLEKKT ATFENIVCVL NREVERVAMT AEACSRQHRL DQDKIEALSS KVQQLERSIG LKDLAMADLE QKVLEMEAST Y

Target Information

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.