Thermo Fisher Scientific ASGR1 Monoclonal Antibody (8D7), FITC
FITC로 표지된 ASGR1 단일클론 항체(8D7)로, 랫트 및 인간 ASGPR에 반응합니다. Western blot, IHC, ICC/IF, Flow cytometry, Inhibition assay에 적합합니다. 단백질 G로 정제되었으며 PBS/1% BSA 용액에 보관됩니다.
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Thermo Fisher Scientific ASGR1 Monoclonal Antibody (8D7), FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:50 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Flow Cytometry (Flow) | 1:50 |
| Inhibition Assays (IA) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8D7 |
| Immunogen | Crude rat liver membrane extracts |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_3093283 |
Product Specific Information
The monoclonal antibody 8D7 is cross reactive with human ASGPR.
Target Information
The asialoglycoprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) mediating binding, internalization, and degradation of extracellular glycoproteins with exposed terminal galactose residues.
It is expressed on hepatocyte surfaces in a polar manner—present on sinusoidal and lateral plasma membranes but not on bile canalicular membranes.
The mammalian hepatic ASGPR mediates endocytosis and degradation of serum proteins lacking terminal sialic residues.
Rat ASGPR consists of three subunits: RHL-1, RHL-2, and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 and is cross-reactive with human ASGPR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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