Thermo Fisher Scientific C1S (Active) Monoclonal Antibody (M241)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:50

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50

-

Immunohistochemistry (Frozen) (IHC (F))

1:50

-

Flow Cytometry (Flow)

1:50

-

Immunoprecipitation (IP)

1:50

-

Functional Assay (Functional)

1:50

-

Inhibition Assays (IA)

1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

M241

Immunogen

Monoclonal antibody M241 reacts with an epitope on human C protein activated C1s

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

100 µg/mL

Purification

Protein G

Storage buffer

PBS with 0.1% BSA

Contains

no preservative

Storage conditions

4° C

Shipping conditions

Wet ice

RRID

AB_3091069

Product Specific Information

The epitope recognised by the antibody M241 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M241 blocks C4 activation and C4 binding to activated C1s. The antibody binds specifically to the active centre of C1s

Target Information

Activated C1s is a protein complex involved in the complement system, which is a part of the innate immune system. C1s is a serine protease that cleaves C4 and C2 in the classical pathway of complement activation, leading to the formation of C3 convertase. The activation of C1s is initiated by binding of C1q to antigen-antibody complexes or other ligands. The C1s protein is encoded by the C1S gene, which is located on chromosome 12. Dysregulation of the complement system and C1s activation has been implicated in various diseases, including autoimmune disorders, infections, and inflammatory conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.