Thermo Fisher Scientific SPACA3 Polyclonal Antibody
SPACA3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, ELISA, IP에 적합합니다. Human, Mouse, Rat에 반응하며, 액상 형태로 제공됩니다. 정제된 항체로 생식 관련 단백질 연구 및 면역학적 분석에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptides taken within amino acid region 50–100 on human sperm acrosome membrane-associated protein 3 isoform 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SPACA3 (sperm acrosome associated 3), also known as sperm lysozyme-like protein 1, lysozyme-like protein 3, lysozyme-like acrosomal sperm-specific secretory protein ALLP-17, cancer/testis antigen 54 (CT54), LYC3, SPRASA, or LYZL3, is a 215 amino acid protein that participates in the fusion and adhesion of sperm and egg plasma membrane during fertilization.
It has been identified as a novel cancer/testis antigen in hematologic malignancies and can elicit B-cell immune responses in cancer patients, making it a potential target for immunotherapy.
A member of the glycosyl hydrolase 22 family, SPACA3 is expressed in testis, placenta, and epididymis. It exists as two alternatively spliced isoforms: isoform 1 (single-pass type II membrane protein of sperm acrosome) and isoform 2 (secreted protein).
SPACA3 may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization and could act as a receptor for egg oligosaccharide residue N-acetylglucosamine. The processed form shows no detectable bacteriolytic activity in vitro.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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