Thermo Fisher Scientific WTAP Monoclonal Antibody (OTI12G6), TrueMAB
WTAP 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot 및 IHC(P) 분석에 적합. 인간, 생쥐, 랫트 반응성. 동결건조 형태로 제공되며, PBS 버퍼에 8% 트레할로스 포함. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI12G6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 2–106 of human WTAP produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Wilms’ tumor (WT) is an embryonal kidney malignancy affecting approximately 1 in 10,000 infants. The Wilms’ tumor protein (WT1) binds to the DNA sequence GCGGGGGCG and acts as a transcriptional repressor.
WTAP (Wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may regulate mRNA splicing. It localizes to nuclear speckles and regulates the G2/M cell cycle transition by binding to the 3′ UTR of cyclin A2, enhancing its stability. WTAP also inhibits expression of WT1 target genes and interferes with WT1 DNA binding. Two isoforms of WTAP exist due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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