Thermo Fisher Scientific CCDC36 Monoclonal Antibody (OTI2D11), TrueMAB
인간 CCDC36 단백질을 인식하는 단클론 항체로, Western blot 및 IHC(P) 적용 가능. 고순도 친화 크로마토그래피 정제, 무보존제 PBS 버퍼에 동결건조 형태로 제공. 연구용으로 DNA 이중가닥 절단 관련 단백질 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D11 |
| Immunogen | Full length human recombinant protein of human CCDC36 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to reach a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform additional desalting using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination.
Acts by forming a complex with MEI4 and REC114, which activates DSBs formation—an essential step for synapsis completion.
Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment, meiotic silencing of unsynapsed chromatin (MSUC), or meiotic surveillance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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