Thermo Fisher Scientific ABCC5 Monoclonal Antibody (OTI6C6), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to achieve a final concentration of approximately 1 mg/mL.
• For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

The protein encoded by the ABCC5 gene belongs to the ATP-binding cassette (ABC) transporter superfamily. These proteins transport various molecules across cellular membranes and are divided into seven subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White.
ABCC5 (MRP5) is part of the MRP subfamily, associated with multidrug resistance. It mediates the cellular export of cyclic nucleotides, influencing phosphodiesterase degradation and nucleotide elimination pathways.
Studies indicate that ABCC5 confers resistance to thiopurine anticancer drugs (6-mercaptopurine, thioguanine) and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. It may play a role in resistance mechanisms in acute lymphoblastic leukemia and HIV-infected patients.
Alternative splicing has been observed, though the full sequence and initiation site remain unclear.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.