Thermo Fisher Scientific POLI Monoclonal Antibody (OTI2C10), TrueMAB
인간 POLI 단백질(aa 458-740)에 특이적인 마우스 단클론 항체로, Western blot에 적합합니다. 동결건조 형태로 제공되며 PBS 완충액(8% trehalose)에 보존됩니다. DNA 수선 연구 및 translesion 합성 관련 연구에 활용 가능합니다.
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Applications
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 458–740 of human POLI produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Error-prone DNA polymerase specifically involved in DNA repair. Plays a critical role in translesion synthesis, allowing DNA synthesis to continue past lesions where high-fidelity polymerases stall. Favors Hoogsteen base-pairing in the active site and inserts the correct base with high fidelity opposite adenosine templates. Shows low fidelity opposite thymidine templates, preferentially inserting guanosine. May contribute to immunoglobulin gene hypermutation. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites but may lack lyase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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