Thermo Fisher Scientific Phospho-C5AR1 (Ser338) Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: 1:50–1:100

Product Specifications

Target Information

CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known.
C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract.

CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release, and superoxide anion production.
It is a component of the classical pathway of the complement cascade and may be involved with tissue injury associated with ischemia or sepsis, as well as the membrane attack complex.

Diseases associated with CD88 include:

• Mannose-Binding Lectin Deficiency
• Systemic Lupus Erythematosus

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.