Thermo Fisher Scientific Phospho-C5AR1 (Ser338) Polyclonal Antibody
Phospho-C5AR1 (Ser338) 폴리클로날 항체로, 인산화된 C5a 수용체 인식. IHC(P)에서 1:50~1:100 희석 사용. Rabbit IgG 기반의 비결합 액상 항체로 -20°C 보관. 면역학 및 염증 관련 연구용에 적합.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human CD88/C5aR around the phosphorylation site of Ser338 (T-R-SP-T-V) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555052 |
Target Information
CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known.
C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract.
CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release, and superoxide anion production.
It is a component of the classical pathway of the complement cascade and may be involved with tissue injury associated with ischemia or sepsis, as well as the membrane attack complex.
Diseases associated with CD88 include:
- Mannose-Binding Lectin Deficiency
- Systemic Lupus Erythematosus
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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