Thermo Fisher Scientific Phospho-CHK1 (Ser286) Polyclonal Antibody
Phospho-CHK1 (Ser286) 항체로, 인간 CHK1 단백질의 Ser286 인산화 부위를 인식합니다. Western blot 및 Immunocytochemistry에 적합하며, Rabbit Polyclonal 형식입니다. 1 mg/mL 농도의 액상 제품으로, -20°C 보관 및 Wet ice 배송 조건을 가집니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human Chk1 around the phosphorylation site of Ser286 (S-E-SP-P-S) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555054 |
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. CHK1 ensures genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, whereas normal cells remain arrested in the G1 phase. Thus, CHK1 inhibitors can enhance the efficacy of DNA-damaging agents in cancer cells, making Chk1 an attractive therapeutic target, especially since about 50% of human cancers are p53-deficient.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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