Thermo Fisher Scientific B7-H3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs and Western blots, approximately 50% cross-reactivity with recombinant human (rh) B7-H3 is observed.
• Less than 1% cross-reactivity with recombinant mouse B7-H1, B7-H2, and B7-1 is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level: <0.10 EU per 1 µg of antibody (LAL method).

Target Information

CD276, also known as B7-H3, is a member of the B7 family of co-stimulatory molecules. It is a type I transmembrane protein that:

• Induces proliferation of CD4⁺ and CD8⁺ T cells
• Enhances cytotoxic T cell generation
• Stimulates interferon gamma production

Expression can be induced on dendritic cells and monocytes by inflammatory cytokines and is found in peripheral tissues such as the heart, kidney, testis, and colon.
In humans, CD276 exists as two isoforms resulting from gene duplication and differential splicing.
CD276 is of therapeutic interest for regulating immune responses in cancer, especially in combination with anti-angiogenic therapy.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.