Thermo Fisher Scientific CD19 Monoclonal Antibody (OTI2B11), TrueMAB
CD19 단백질을 인식하는 마우스 모노클로날 항체로, Western blot, ICC/IF, Flow Cytometry 등에 사용 가능. Human CD19 전체 길이 단백질을 면역원으로 제작. Lyophilized 형태로 제공되며, 재구성 후 1 mg/mL 농도. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:4,000 | |
| Immunocytochemistry (ICC/IF) | 1:100 | |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B11 |
| Immunogen | Full length human recombinant protein of human CD19 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
CD19 is a member of the immunoglobulin superfamily with two Ig-like domains. It is expressed on 100% of peripheral B cells and may also be present on certain myeloid leukemia cells. CD19 acts as a key regulator of normal and malignant B cell proliferation and is expressed in all B cell precursor leukemias.
As a signal-amplifying coreceptor for the B cell receptor (BCR), CD19 lowers the threshold for antigen receptor-dependent stimulation. It can also signal independently of BCR co-ligation, serving as a central regulatory component for multiple signaling pathways.
Mutation of the CD19 gene can result in hypogammaglobulinemia, while overexpression leads to B cell hyperactivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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