Thermo Fisher Scientific PIEZO1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Piezo1 is a pore-forming subunit of a mechanosensitive non-specific cation channel that generates currents characterized by a linear current-voltage relationship sensitive to ruthenium red and gadolinium. Structurally, Piezo1 contains 36 transmembrane domains and functions as a homotetramer.

Piezo1 plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER and subsequent stimulation of calpain signaling. In the kidney, it may contribute to sensing intraluminal pressure changes and urine flow. It acts as a shear-stress sensor promoting endothelial cell organization and alignment in the direction of blood flow, playing a crucial role in blood vessel formation and vascular structure during development and in adult physiology.

Defects in the PIEZO1 gene have been associated with dehydrated hereditary stomatocytosis and related disorders such as pseudohyperkalemia, perinatal edema, and lymphedema.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.