Thermo Fisher Scientific FAT4 Polyclonal Antibody
FAT4 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등에 사용 가능. Human 및 Mouse 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 1.0 mg/mL 농도의 액상 형태로 제공되며, 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-Dependent | View 2 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to a C-terminal portion of the human FAT4 protein (between residues 4000–4500) [UniProt Q6V0I7] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718824 |
Target Information
FAT1, FAT2, FAT3, and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP).
FAT4 undergoes the first proteolytic cleavage by Furin and is predicted to undergo a second cleavage by secretase to release the intracellular domain (ICD).
FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane-associated guanylate kinase MPP5/PALS1.
FAT4 is involved in maintaining PCP and inhibiting cell proliferation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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