Thermo Fisher Scientific DOCK11 Polyclonal Antibody
DOCK11 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제된 1 mg/mL 액상 형태. 인간 반응성으로, 세포 극성 및 신호전달 연구에 적합.
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Applications
Western Blot (WB)
- Assay-dependent
Immunoprecipitation (IP)
- 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 100 and 150 of human dedicator of cytokinesis 11 (DOCK11, UniProt ID: Q5JSL3-1, antigen length: 2073 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
Small GTPases of the Rho family (Rho, Rac, and Cdc42) are critical regulators of the actin cytoskeleton and various cellular processes.
Rho GTPases are activated by Dbl-homology (DH)-domain-containing guanine nucleotide exchange factors (GEFs).
DOCK11 (dedicator of cytokinesis 11), also known as ACG or ZIZ2 (zizimin2), is a 2073 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins, mainly expressed in peripheral blood leukocytes.
DOCK11 functions as a GEF that binds and activates Cdc42 by exchanging bound GDP for free GTP.
Cdc42 mediates cell polarity, gene expression, cell cycle progression, and cell-cell contacts.
Similar to other DOCK family members, DOCK11 contains a PH domain and two internal DOCK homology regions designated DHR1 and DHR2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: A301-638A_DOCK11_Q5JSL3-1_Rabbit.svg, A301-638A_DOCK11_Q5JSL3-1_Rabbit_PDP.jpeg)
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