Thermo Fisher Scientific SPTBN1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Spectrin beta-1. Recombinant protein control fragment (Product #RP-89903). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SPTBN1,uniProtId:Q01082-1,ncbiNodeId:9606,antigenRange:744-869,antigenLength:2364,antigenImageFileName:PA5-53024_SPTBN1_Q01082-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53024_SPTBN1_Q01082-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647833

Product Specific Information

Immunogen sequence: SLLHQFQADA DDIDAWMLDI LKIVSSSDVG HDEYSTQSLV KKHKDVAEEI ANYRPTLDTL HEQASALPQE HAESPDVRGR LSGIEERYKE VAELTRLRKQ ALQDTLALYK MFSEADACEL WIDEKE

Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

Target Information

Spectrin (Sp), the most abundant of the erythrocyte membrane skeleton proteins, helps these cells maintain their characteristic biconcave shape while remaining flexible and elastic. Erythrocyte Sp is a heterodimer composed of a 280 kDa alpha subunit and a 246 kDa beta subunit which associate in a side-to-side, antiparallel configuration to form a 100 nm rod-like structure. Sp in other tissues may be composed of distinct but homologous alpha and beta subunits, sometimes referred to as fodrin. A newly introduced nomenclature designates the Sp subunits of the erythrocyte as alpha-1 and beta-1, and the fodrin subunits as alpha-2 and beta-2. Alternatively spliced forms of each are designated as epsilon-1, epsilon-2, etc. (e. g. beta-1 epsilon-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.