Thermo Fisher Scientific SCG5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SCG5. Recombinant protein control fragment (Product #RP-89933). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SCG5,uniProtId:P05408-1,ncbiNodeId:9606,antigenRange:80-201,antigenLength:212,antigenImageFileName:PA5-53020_SCG5_P05408-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53020_SCG5_P05408-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2646999

Product Specific Information

Immunogen sequence: EGLQHLGPFG NIPNIVAELT GDNIPKDFSE DQGYPDPPNP CPVGKTADDG CLENTPDTAE FSREFQLHQH LFDPEHDYPG LGKWNKKLLY EKMKGGERRK RRSVNPYLQG QRLDNVVAKK SV

Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

Target Information

Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.