Thermo Fisher Scientific PELI1 Monoclonal Antibody (OTI13F8), TrueMAB
Human PELI1 단백질(aa 1-245)을 항원으로 제작된 Mouse IgG1 단일클론 항체. Western blot 및 IHC(Paraffin) 검증 완료. Affinity chromatography로 정제된 액상형 항체로, -20°C 보관. Toll-like receptor 신호전달 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI13F8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–245 of human PELI1 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways leading to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, resulting in activation of NF-Kappa-B. Like other Pellino family members, Pellino 1 catalyzes polyubiquitination of IRAK1 and is activated via phosphorylation by IRAK1, IRAK4, IKK-epsilon, or TBK1. Its activity is further modulated via ubiquitination and sumoylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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