Thermo Fisher Scientific Phospho-Stat4 (Tyr693) Recombinant Rabbit Monoclonal Antibody (Stat4Y693-F6), APC

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

5 µL/1x10^6 cells

-

Product Specifications

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

Stat4Y693-F6

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Tyr693 of human phospho Stat4. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:STAT4,uniProtId:Q14765-1,ncbiNodeId:9606,antigenRange:693,antigenLength:748,antigenImageFileName:MA5-37082_STAT4_Q14765-1_Rabbit.svg,antigenImageFileNamePDP:MA5-37082_STAT4_Q14765-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

APC APC APC

View additional formats

• Unconjugated
• Request custom conjugation

Excitation/Emission Max

651/660 nm View spectra

Form

Liquid

Storage conditions

2-8°C

Shipping conditions

Wet ice

Target Information

STAT4 was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins. The STAT4 protein is most similar to STAT1 (52%) and STAT3 (47%). Functionally, STAT4 is similar to other STAT family members in that it can be tyrosine phosphorylated by Jak1 or Jak2. STAT4 forms homodimers and heterodimers with related STAT family members. Tyrosine phosphorylated STAT4 can bind the IFN-gamma activated site (GAS). Serine phosphorylation of STAT is also required for maximal transcriptional activity. STAT4 expression is restricted to the thymus, spleen and testis. Until recently the cytokine(s) responsible for activation of STAT4 had not been identified. STAT4 is now known to be activated by the cytokine interleukin 12 (IL-12). IL-12 is required for the T-cell independent induction of IFN-gamma which is a key step in the initial suppression of bacterial and parasitic infections. In addition, IL-12 is required for the development of a Th1 response which is necessary for effective host defense against intracellular pathogens. STAT4-deficient mice display impaired IL-12 development of Th1 cells and enhanced development of Th2 cells. A recent study in mouse has shown that in response to viral infection IFN-a/b activation of STAT4 is required for IFN-g production.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.