Thermo Fisher Scientific Phospho-Stat4 (Tyr693) Recombinant Rabbit Monoclonal Antibody (Stat4Y693-F6), APC

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 5 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Target Information

STAT4 was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins. The STAT4 protein is most similar to STAT1 (52%) and STAT3 (47%). Functionally, STAT4 can be tyrosine phosphorylated by Jak1 or Jak2 and forms homodimers and heterodimers with related STAT family members. Phosphorylated STAT4 binds the IFN-gamma activated site (GAS), and serine phosphorylation is required for maximal transcriptional activity.

STAT4 expression is restricted to the thymus, spleen, and testis. It is activated by interleukin 12 (IL-12), which is essential for T-cell independent induction of IFN-gamma and Th1 response development. STAT4-deficient mice show impaired IL-12-mediated Th1 development and enhanced Th2 differentiation. IFN-α/β activation of STAT4 is required for IFN-γ production during viral infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지