Thermo Fisher Scientific Human Caspase 5 Synthetic Peptide

Thermo Fisher Scientific Human Caspase 5 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the amino terminus of human Caspase-5.
PEP-0228 can be used as a blocking peptide with polyclonal antibody PA5-20110.

Target Information

Caspases are a family of cysteine proteases divided into apoptotic and inflammatory subfamilies.
Unlike apoptotic caspases, inflammatory caspases are associated with immune responses to microbial pathogens.
Members include caspase-1, -4, -5, and -12. Activation of these caspases leads to cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18.
Caspase-5 interacts with caspase-1; both are constituents of the NALP1 inflammasome, which triggers cleavage of pro-IL-1β.
Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-γ.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.