Thermo Fisher Scientific Kir3.4 (KCNJ5) Polyclonal Antibody
인간, 마우스, 랫트 반응성의 Kir3.4(KCNJ5) 폴리클로날 항체로, Western blot과 ELISA에 적합합니다. 합성 펩타이드(AA 50-150)를 면역원으로 사용하였으며, PBS/glycerol 용액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 50–150 of human KCNJ5 (NP_000881.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.42 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806509 |
Product Specific Information
- Immunogen sequence: RQRYMEKSGK CNVHHGNVQE TYRYLSDLFT TLVDLKWRFN LLVFTMVYTV TWLFFGFIWW LIAYIRGDLD HVGDQEWIPC VENLSGFVSA FLFSIETETT I
- Positive Samples: Mouse pancreas, Rat heart
- Cellular Location: Membrane, Multi-pass membrane protein
Target Information
G protein-coupled inwardly rectifying potassium channels (Kir3.1–Kir3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex, and thalamus. Also known as GIRK channels, they localize to soma, dendrites, and axons of neurons. Gβγ subunits from G protein heterotrimers regulate Kir3 channel activity—Gβ3/β4-containing dimers increase K⁺ current, while Gβ5-containing dimers inhibit it. Kir3 channels are also inhibited by tyrosine phosphorylation mediated by receptor tyrosine kinase B activation via brain-derived neurotrophic factor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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