Thermo Fisher Scientific LOX Monoclonal Antibody (OTI9G6), TrueMAB
인간 LOX 단백질(aa 22-168)을 인식하는 마우스 단클론 항체로, WB, IHC, ICC/IF에 적합. 무보존제·동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도 유지 가능. 세포외기질 형성 및 종양 억제 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9G6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–168 of human LOX produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Lysyl oxidase (LOX) is a copper-containing amine oxidase that oxidizes primary amine substrates to reactive aldehydes. It plays a key role in extracellular matrix formation and repair and exhibits diverse biological functions including developmental regulation, tumor suppression, cell motility, and cellular senescence.
The secreted form of LOX contributes to the invasiveness of hypoxic cancer cells and is essential for hypoxia-induced metastasis, making it a promising therapeutic target for metastasis prevention and treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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