Thermo Fisher Scientific CHRM3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CHRM3, validated for WB and ELISA. Recognizes amino acids 390–475 of CHRM3. Supplied in liquid form, affinity purified, unconjugated. Suitable for research use in studying muscarinic receptor signaling and mem...
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 390–475 of human CHRM3 (NP_0007311) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.57 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805833 |
Product Specific Information
- Immunogen sequence: QVPEEELGMV DLERKADKLQ AQKSVDDGGS FPKSFSKLPI QLESAVDTAK TSDVNSSVGK STATLPLSFK EATLAKRFAL KTRSQI
- Positive Samples: SH-SY5Y, U-251MG, U-87MG
- Cellular Location: Basolateral cell membrane, Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Target Information
The muscarinic cholinergic receptors belong to a family of G protein-coupled receptors. Their functional diversity arises from acetylcholine binding, leading to cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors modulate various acetylcholine effects in the central and peripheral nervous systems. The muscarinic cholinergic receptor 3 (CHRM3) regulates smooth muscle contraction and stimulates glandular secretion.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm. For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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