Thermo Fisher Scientific Factor X/Xa Polyclonal Antibody

Thermo Fisher Scientific Factor X/Xa Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

PA1-43047 detects Factor X in human samples.
PA1-43047 has been successfully used in Western blot and ELISA applications.
PA1-43047 was derived from human Factor X.

Target Information

Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by excision of the tripeptide RKR.
Two chains are held together by one or more disulfide bonds:

• The light chain contains two EGF-like domains.
• The heavy chain contains the catalytic domain, homologous to other hemostatic serine proteases.

The mature factor is activated by cleavage of the activation peptide by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway).
Activated Factor X converts prothrombin to thrombin in the presence of factor Va, Ca²⁺, and phospholipid during blood clotting.
Mutations of this gene can result in Factor X deficiency, a hemorrhagic condition of variable severity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.