Thermo Fisher Scientific SHANK2 Polyclonal Antibody
SHANK2 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. 단백질 A 정제, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human SHANK2 (amino acids 161–260) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The SHANK2 gene encodes a member of the Shank family of synaptic proteins, which act as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins include multiple protein–protein interaction domains such as ankyrin repeats and SH3 domains. SHANK2 contains a PDZ domain, a cortactin SH3-binding consensus sequence, and a sterile alpha motif. Alternative splicing may regulate the structural diversity and interaction spectrum of Shank proteins in the brain. Mutations or alterations in SHANK2 have been associated with autism spectrum disorder. Multiple transcript variants are produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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