Thermo Fisher Scientific Spectrin beta-3 Polyclonal Antibody
Human Spectrin beta-3 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 버퍼에 보존. 세포막-세포골격 연구 및 신경퇴행성 질환 관련 연구에 적합.
- 카탈로그번호
- PA558724
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Spectrin beta-3. Recombinant protein control fragment (Product #RP-103917) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2647834 |
Product Specific Information
Immunogen sequence:
PPPSTQAPSV NGVCTDGEPS QPLLGQQRLE HSSFPEGPGP GSGDEANGPR GERQTRTRGP APSAMPQSRS TESAH
Highest antigen sequence identity to orthologs:
- Mouse: 77%
- Rat: 79%
Target Information
Spectrins are principal components of a cell’s membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits.
The protein encoded by this gene (SPTBN2), known as spectrin beta non-erythrocytic 2 or beta-III spectrin, is distinct from beta-II spectrin (SPTBN1).
SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the plasma membrane surface.
Mutations in SPTBN2 cause spinocerebellar ataxia type 5 (SCA5), characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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