Thermo Fisher Scientific DIS3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human DIS3. Recombinant protein control fragment (Product #RP-97922). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DIS3,uniProtId:Q9Y2L1-1,ncbiNodeId:9606,antigenRange:849-943,antigenLength:958,antigenImageFileName:PA5-58723_DIS3_Q9Y2L1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-58723_DIS3_Q9Y2L1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640613

Product Specific Information

Immunogen sequence: EAYILFVRKN AIVVLIPKYG LEGTVFFEEK DKPNPQLIYD DEIPSLKIED TVFHVFDKVK VKIMLDSSNL QHQKIRMSLV EPQIPGISIP TDTSN

Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 87%.

Target Information

The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.