Thermo Fisher Scientific Phospho-HMGN1 (Ser21) Polyclonal Antibody
HMGN1 단백질의 Ser21 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, IHC, ICC/IF, peptide-ELISA에 사용 가능. 고농도(1 mg/mL) 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Peptide-ELISA (pep-ELISA) | 1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human HMG14 around the phosphorylation site of Ser21 (R-R-SP-A-R) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555185 |
Target Information
The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription.
HMG-14 and HMG-17 also function as architectural elements, altering chromatin fiber structure and enhancing transcription from chromatin templates.
These proteins modify nucleosomal organization of the 30 nm chromatin fiber, mediating unfolding of higher-order chromatin structures and facilitating DNA access.
Clustering of architectural elements such as HMG proteins and linker histone subtypes into distinct domains may lead to structural and functional heterogeneity along the chromatin fiber.
Additionally, HMG-14 and HMG-17 have been identified as constitutive components of mouse oocyte and embryonic chromatin, linking chromatin structure to embryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-38586_HMGN1_P05114-1_Rabbit.svg, PA5-38586_HMGN1_P05114-1_Rabbit_PDP.jpeg)
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