Thermo Fisher Scientific HMGN1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription. HMG-14 and HMG-17 also function as architectural elements that alter the structure of the chromatin fiber and enhance transcription from chromatin templates. These proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of higher-order chromatin structures, facilitating access to the underlying DNA sequence.

Clustering of architectural elements, such as HMG proteins and linker histone subtypes into distinct domains, may lead to structural and functional heterogeneity along the chromatin fiber. Furthermore, HMG-14 and HMG-17 are constitutive components of mouse oocyte and embryonic chromatin, linking chromatin structure to embryonic development progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.