Thermo Fisher Scientific HMGN1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human HMGN1, suitable for IHC and ICC applications. Unconjugated form with 1 mg/mL concentration. Enhances transcription by modifying chromatin structure. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human HMG14 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555186 |
Target Information
The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription. HMG-14 and HMG-17 also function as architectural elements that alter the structure of the chromatin fiber and enhance transcription from chromatin templates. These proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of higher-order chromatin structures, facilitating access to the underlying DNA sequence.
Clustering of architectural elements, such as HMG proteins and linker histone subtypes into distinct domains, may lead to structural and functional heterogeneity along the chromatin fiber. Furthermore, HMG-14 and HMG-17 are constitutive components of mouse oocyte and embryonic chromatin, linking chromatin structure to embryonic development progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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