Thermo Fisher Scientific APE1 Recombinant Rabbit Monoclonal Antibody (23GB1220)
APE1 단백질을 인식하는 토끼 유래 재조합 단일클론 항체입니다. Western blot 및 유세포분석에 적합하며, 인간, 생쥐, 랫드 시료에 반응합니다. 고순도 친화 크로마토그래피 정제, PBS/glycerol 완충액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB1220 |
| Immunogen | A synthesized peptide derived from human APE1 (1–62 AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | –20°C |
| Shipping conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional enzyme involved in DNA repair and redox regulation of various transcription factors (Fos, Jun, NF-κB, Myb, HIF-1α, CREB, Pax). It repairs abasic sites in DNA caused by oxidative stress, radiation, or chemical damage. APE1 expression varies across tissues and developmental stages, and its regulation involves phosphorylation by casein kinase II. Increased APE1 expression is observed upon reoxygenation of hypoxic cells and in certain malignant tissues, while decreased expression has been linked to apoptosis induction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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