Thermo Fisher Scientific Daclizumab Recombinant Human Monoclonal Antibody (Daclizumab)
Daclizumab 재조합 인간 단클론 항체로, IL-2 수용체 p55 사슬(Tac antigen)에 특이적으로 결합합니다. Western blot, IHC, Flow cytometry 등 다양한 응용에 적합하며, 인간 및 원숭이 종에 반응합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1.5 µg/mL | |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 5 µg/mL | |
| Flow Cytometry (Flow) | Assay-dependent | |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Cynomolgus monkey, Human, Rhesus monkey |
| Host / Isotype | Human / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Daclizumab |
| Immunogen | Cultured T-cells derived from a patient with Mycosis fungoides |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074279 |
Product Specific Information
Specificity: Binds to p55 chain of IL-2 receptor (IL2R) on human T cells, known as Tac antigen. This antigen is expressed on T cells activated by mitogens, soluble antigens, and alloantigens but not on resting T cells, thymocytes, B cells, monocytes, activated B cells, leukemic T cell blasts from patients with acute lymphoblastic leukemia, and long-term T cell lines.
Target Information
Daclizumab is a humanized IgG1 monoclonal antibody that binds to the human interleukin-2 receptor (anti-Tac or anti-CD25). It is composed of approximately 90% human and 10% murine antibody sequences.
- Human sequences are derived from the constant domains of human IgG1 and the variable framework regions of the Eu myeloma antibody.
- Murine sequences are derived from the complementarity-determining regions of a murine anti-Tac antibody.
On April 22, 2008, Roche Registration Limited voluntarily withdrew the marketing authorization for Zenapax (daclizumab), used for the prophylaxis of acute organ rejection in de novo allogeneic renal transplantation. This withdrawal was for commercial reasons and not due to safety concerns.
Later, Biogen and Abbvie’s Zinbryta (daclizumab) was approved by the FDA in 2016 for the treatment of adult patients with relapsing forms of multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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