Thermo Fisher Scientific GNA11 Polyclonal Antibody
GNA11 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS와 50% 글리세롤 용액 형태로 제공되며, -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–20 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein G Protein Alpha 11 (amino acids 1–359 of the target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903630 |
Target Information
Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β, and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines, and sensory stimuli. Over 20 known Gα subunits have been classified into four families — Gα(s), Gα(i/o), Gα(q), and Gα(12) — based on structural and functional similarities. Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, as substitution of Tyr356 with phenylalanine alters receptor interaction and abolishes ligand-induced IP3 formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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