Thermo Fisher Scientific Decorin Recombinant Rabbit Monoclonal Antibody (004)

Applications

• ELISA (ELISA)
  Tested dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

This antibody has specificity for Human Decorin/DCN/SLRR1B.

Target Information

Decorin is a member of the small leucine-rich proteoglycan (SLRP) family along with biglycan. Found in the interterritorial region of cartilage, decorin interacts with collagen and other matrix proteins to regulate the cartilaginous matrix. It interacts with fibronectin, thrombospondin, C1q, epidermal growth factor receptor (EGFR), and TGF-β. Decorin is also believed to play a role in the cell cycle of chondrocytes.

The decorin neoepitope fragment has a sequence of PKTLQE and is generated by MMP-3 or ADAMTS-4 cleavage at Glu154–Leu155 of the decorin core protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.