Thermo Fisher Scientific beta Amyloid Polyclonal Antibody
베타 아밀로이드 단백질을 인식하는 Rabbit Polyclonal 항체로, Alzheimer 연구에 적합. Western blot, IHC, ICC, IP 등 다양한 응용 가능. Human 및 Mouse 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 13 publications |
| Immunohistochemistry (IHC) | Assay-dependent | View 7 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 1 publication |
| Immunohistochemistry - Free Floating (IHC (Free)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 2 publications |
| ELISA | – | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | View 3 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Ferret, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the C-terminal region of the human and mouse amyloid-beta precursor protein (APP695) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533275 |
Product Specific Information
For immunohistochemistry in formalin-fixed, paraffin-embedded tissues, digestion with trypsin prior to staining is required.
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide (40–43 amino acids) is generated from the beta-amyloid precursor protein (beta APP) in a two-step process involving beta-secretase (BACE) and gamma-secretase.
Gamma-secretase, a multi-subunit complex containing presenilin-1 and -2, cleaves the carboxyl-terminal domain of beta APP to generate amyloid beta peptide.
Abeta is an extracellular filamentous protein found in amyloid cores, neuritic plaques, and neurofibrillary tangles. Beta amyloid deposits are associated with Alzheimer’s disease, Lewy body dementia, Down’s syndrome, and other amyloidoses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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