Thermo Fisher Scientific MPZ Polyclonal Antibody
Rabbit polyclonal antibody targeting human MPZ (Myelin Protein Zero). Validated for WB, IHC (P), and Flow Cytometry. Supplied as liquid form, 0.5 mg/mL in PBS with sodium azide. Suitable for research use in studying myelin structure and neuropathies.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 186–215 of the C-terminal region of human MPZ |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718395 |
Target Information
Zero, also known as myelin protein zero (MPZ), is a type I integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath to ensure stable synaptic transmission. MPZ constitutes approximately 50% of the total protein in the sheath scaffolding, contributing to the structural integrity of peripheral myelin. It guides compact myelin wrapping through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations such as G134R can disrupt multimer formation, cause demyelinating neuropathies, and contribute to conditions including Charcot–Marie–Tooth disease. The cytoplasmic domain undergoes serine and tyrosine phosphorylation, prevalent during peak nerve myelination. MPZ transcript levels are moderate in brain, abundant in thymus, and most abundant in white matter of the CNS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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