Thermo Fisher Scientific ALK/p80 Polyclonal Antibody
ALK/p80 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot과 IHC(Paraffin)에 적합합니다. Human, Mouse, Rat에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 뇌 발달 연구 및 종양 관련 ALK 변이 분석에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide RDIYRASYYRKGG corresponding to human ALK/p80 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Not specified
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is essential for brain development. Mutations, rearrangements, and amplifications in the ALK gene are associated with various tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangements often create a fusion gene between ALK (chromosome 2) and NPM (chromosome 5), producing the oncogenic NPM-ALK fusion protein.
ALK encodes a receptor tyrosine kinase with transmembrane and extracellular domains, absent in the NPM-ALK fusion product. It shows high sequence similarity to LTK and plays a crucial role in neuronal development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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