Thermo Fisher Scientific BCL2A1 Polyclonal Antibody
BCL2A1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 최적화되어 있으며, 인간, 마우스, 랫트 시료에 반응. 항원 친화 크로마토그래피로 정제된 액상 항체로 4°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 2 µg/mL | — |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide from near the amino terminus of human Bfl-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156205 |
Product Specific Information
Despite the predicted molecular weight, Bfl-1 often migrates at a higher molecular weight in SDS-PAGE, presumably due to post-translational modifications.
A suggested positive control is mouse kidney tissue lysate.
PA5-20269 can be used with blocking peptide PEP-0384.
Target Information
Bcl-2 related Protein A1 (BCL2A1) is a member of the BCL-2 protein family. These proteins form hetero- or homodimers and act as anti- and pro-apoptotic regulators involved in various cellular activities such as embryonic development, homeostasis, and tumorigenesis.
This protein reduces the release of pro-apoptotic cytochrome c from mitochondria and blocks caspase activation.
It is a direct transcription target of NF-kappa B in response to inflammatory mediators and can be up-regulated by signals such as GM-CSF, CD40, phorbol ester, TNF, and IL-1, indicating a cytoprotective function essential for lymphocyte activation and cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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