Thermo Fisher Scientific LRRFIP1 Monoclonal Antibody (2D3)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1 µg/mL

-

Immunocytochemistry (ICC/IF)

10 µg/mL

-

ELISA (ELISA)

1 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

2D3

Immunogen

LRRFIP1 (NP_004726, 675 a.a. approximately 784 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LRRFIP1,uniProtId:Q32MZ4-1,ncbiNodeId:9606,antigenRange:675-784,antigenLength:808,antigenImageFileName:H00009208-M02_LRRFIP1_Q32MZ4-1_House_mouse.svg,antigenImageFileNamePDP:H00009208-M02_LRRFIP1_Q32MZ4-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: GVAKDNAKID GATQSSPAEP KSEDADRCTL PEHESPSQDI SDACEAESTE RCEMSEHPSQ TVRKALDSNS LENDDLSAPG REPGHFNPES REDTRGGNEK GKSKEDCTMS

Target Information

Leucine-rich repeat FLI-I interacting protein 1 (LRRFIP1/FLAP-1) is a MyD88-interacting signal protein which mediates either induction or repression of TLR signaling. Flap-1 directly interacts with β-catenin and activates β-catenin-dependent transcription activity. Flap-1 or LRRFIP1 was also shown to bind the TNF- -308 promoter polymorphism site, suggesting its possible role in the regulation of TNF- production. FLAP-1 along with LRRFIP2 and FLIIH serve as a balance in coordinating inflammatory response after infection, and may act as a novel target in the control of agonist-induced TLR-mediated inflammatory and autoimmune diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.