Thermo Fisher Scientific LRRFIP1 Monoclonal Antibody (2D3)
인간 LRRFIP1 단백질을 인식하는 마우스 모노클로날 항체로, WB, IHC, ICC, ELISA에 적합. GST 태그가 포함된 재조합 항원으로 제작. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2D3 |
| Immunogen | LRRFIP1 (NP_004726, 675–784 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GVAKDNAKID GATQSSPAEP KSEDADRCTL PEHESPSQDI SDACEAESTE RCEMSEHPSQ TVRKALDSNS LENDDLSAPG REPGHFNPES REDTRGGNEK GKSKEDCTMS
Target Information
Leucine-rich repeat FLI-I interacting protein 1 (LRRFIP1/FLAP-1) is a MyD88-interacting signal protein that mediates induction or repression of TLR signaling.
Flap-1 directly interacts with β-catenin and activates β-catenin-dependent transcription activity.
It also binds the TNF- -308 promoter polymorphism site, suggesting a role in TNF- production regulation.
FLAP-1, LRRFIP2, and FLIIH coordinate inflammatory responses after infection and may serve as targets in controlling TLR-mediated inflammatory and autoimmune diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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