Thermo Fisher Scientific STAT4 Monoclonal Antibody (OTI1G9), Biotin, TrueMAB
STAT4 단백질을 인식하는 Biotin 결합 단클론 항체로, ELISA 및 Luminex 분석에 적합. 인간 시료 반응성, Mouse IgG1 아이소타입. 고순도 친화 크로마토그래피 정제, 안정한 PBS/BSA/glycerol 완충액 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| ELISA (ELISA) | 1:250–1:1,000 |
| Luminex (LUM) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G9 |
| Immunogen | Full length human recombinant protein of human STAT4 produced in HEK293T cell |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 10 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
STAT4 was originally identified using degenerate primers complementary to conserved regions of other STAT proteins. The STAT4 protein shares similarity with STAT1 (52%) and STAT3 (47%). Functionally, it can be tyrosine phosphorylated by Jak1 or Jak2, forming homo- and heterodimers with other STAT family members. Phosphorylated STAT4 binds to the IFN-gamma activated site (GAS), and serine phosphorylation is required for maximal transcriptional activity.
STAT4 expression is restricted to the thymus, spleen, and testis. It is activated by interleukin 12 (IL-12), which induces IFN-gamma production and supports Th1 cell development for effective defense against intracellular pathogens. STAT4-deficient mice show impaired Th1 and enhanced Th2 cell development. During viral infection, IFN-α/β activation of STAT4 is required for IFN-γ production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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