Thermo Fisher Scientific TNFSF15 Monoclonal Antibody (2H3)
Human TNFSF15 단백질을 인식하는 Mouse monoclonal antibody (Clone 2H3). Western blot 및 ELISA에 적합하며, PBS 기반의 액상 형태로 제공. TNF ligand family의 TL1A 단백질 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2H3 |
| Immunogen | TNFSF15 (AAH74941.1, 72 a.a. approximately 251 a.a) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
LKGQEFAPSH QQVYAPLRAD GDKPRAHLTV VRQTPTQHFK NQFPALHWEH ELGLAFTKNR MNYTNKFLLI PESGDYFIYS QVTFRGMTSE CSEIRQAGRP NKPDSITVVI TKVTDSYPEP TQLLMGTKSV CEVGSNWFQP IYLGAMFSLQ EGDKLMVNVS DISLVDYTKE DKTFFGAFLL
Target Information
This gene encodes a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It is abundantly expressed in endothelial cells but not in B or T cells. Expression is inducible by TNF and IL-1α.
This cytokine is a ligand for TNFRSF25 and decoy receptor TNFRSF21/DR6. It activates NF-κB and MAP kinases and acts as an autocrine factor inducing apoptosis in endothelial cells. It also inhibits endothelial cell proliferation, functioning as an angiogenesis inhibitor.
An additional isoform encoded by an alternatively spliced transcript variant has been reported, though its sequence has not been determined.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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